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Bibliographic Data

  • Authors: Stephan, T., Roesch, A., Riedel, D., Jakobs, S.
  • Title: Live-cell STED microscopy of mitochondrial cristae
  • Journal: BioRxiv
  • DOI: 10.1101/640920


Mitochondria are highly dynamic organelles that exhibit a complex inner architecture. They exhibit a smooth outer membrane and a highly convoluted inner membrane that forms invaginations called cristae. Imaging cristae in living cells poses a formidable challenge for light microscopy. Relying on a cell line stably expressing the mitochondrial protein Cox8A fused to the SNAP-tag and using STED (stimulated emission depletion) super-resolution microscopy, we demonstrate the visualization of cristae dynamics in cultivated human cells.