In the RNApp Graduate School, universities, clinics and Fraunhofer Institutes develop pioneering innovations in basic research and open up the translation of the results into clinical practice. The focus is on RNA-based therapeutics and therapies. They are characterized in particular by the fact that they have the potential to exceed the possibilities of classical biopharmaceuticals but are not classical gene therapeutics. The challenges of therapeutic RNA variants include production, formulation, and stabilization as well as its transport to their sites of action in the body which are the cells. RNApp is oriented to precisely this pathway. It pools and extends expertise on the most pressing manufacturing and delivery issues through R&D.

The focus is on process development for molecular targeting and tracking, for stabilization through formulation and drying through to monitoring of delivery. The clinical delivery spectrum ranges from inhalanda and parenterals to implants and smart primary packagings with functionalized surfaces. The experimental work is accompanied by simulation and modelling. A total of 12 research topics are divided into 3 clusters for this purpose: A) Formulation, Targeted Delivery and Tracking, B) Production Processes, Simulation and Packaging and C) Functional Implants. The RNApp Graduate School sets measurable translational goals for pharmaceutical manufacturing technology and its economic implementation in the state of Lower Saxony.

Find more information about the RNApp Graduate School on the web: https://zukunft.niedersachsen.de/graduierten-kolleg-fur-rna-anwendungen-in-medizin-und-pharmazie

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