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Publications

The press about us:

How the cell's powerhouses get in shape. Press release by MPIBPC News (15.07.2020)

ERC Advanced Grant for Research on Mitochondria. Press releases by MPIBPC, UMG, Göttinger Tageblatt (19.06.2019)

Ein Auge für Details. Artikel in der Apotheken Umschau  (01.09.2016)

Reversibel schaltbare fluoreszierende Proteine für die Superauflösung. BIOspektrum  (27.06.2016)

Türöffner für den Selbstmord. Göttinger Tageblatt (20.01.2016)

Ein Trick macht Blick in lebende Zellen möglich. Göttinger Tageblatt (09.12.2011)

Mikroskopie: Liveschaltung ins Mäusehirn. Spiegel (05.02.2010)

3-D-Mikroskopie: Forscher fotografieren das Innere der Zellkraftwerke. Spiegel Online (28.05.2009)

2021

Konen T., Stumpf D., Grotjohann T., Jansen I., Bossi M., Weber M., Jensen N., Hell S. W., Jakobs S.: "The Positive Switching Fluorescent ProteinPadron2 Enables Live-Cell ReversibleSaturable Optical Linear FluorescenceTransitions (RESOLFT) Nanoscopy withoutSequential Illumination Steps"
ACS Nano. DOI 10.1021/acsnano.0c08207Details

Lange F., Agüi-Gonzalez P., Riedel D., Phan N.T.N., Jakobs S., Rizzoli S. O.: "Correlative fluorescence microscopy, transmission electron microscopy and secondary ion mass spectrometry (CLEM-SIMS) for cellular imaging"
PLoS One 16 (5). DOI 10.1371/journal.pone.0240768Details

Yousefi R., Fornasiero E.F., Cyganek l., Montoya J., Jakobs S., Rizzoli S.O., Rehling P., Pacheu‐Grau D.: "Monitoring mitochondrial translation in living cells"
EMBO Reports 22 (4), e51635. DOI 10.15252/embr.202051635Details

Weber M., Leutenegger M., Stoldt S., Jakobs S., Mihaila T.S., Butkevich A.N. and Hell S.W.: "MINSTED fluorescence localization and nanoscopy"
Nature Photonics 15, 361-366. DOI 10.1038/s41566-021-00774-2Details

2020

Ruhlandth D., Andresen M., Jensen N., Gregor I., Jakobs S., Enderlein J., Chizhik A.: "Absolute quantum yield measurements of fluorescent proteins using a plasmonic nanocavity"
Communications Biology 3, 627. DOI 10.1038/s42003-020-01316-2Details

Schnorrenberg S., Ghareeb H., Frahm L., Grotjohann T., Jensen N., Teichmann T., Hell S.W., Lipka V., Jakobs S.: "Live‐cell RESOLFT nanoscopy of transgenic Arabidopsis thaliana"
Plant Direct 4 (9), e00261. DOI 10.1002/pld3.261Details

Pape J.K., Stephan T., Balzarotti F., Büchner R., Lange F., Riedel D., Jakobs S.*, and Hell S.W.*: "Multicolor 3D MINFLUX nanoscopy of mitochondrial MICOS proteins"
Proc. Natl. Acad. Sci. USA 117 (34), 20607-20614. DOI 10.1073/pnas.2009364117. (*shared corresponding authors) Highlighted in PNASDetails

Stephan T., Brüser C., Deckers M., Steyer A. M., Balzarotti F., Barbot M., Behr T. S., Heim G., Hübner W., Ilgen P., Lange F., Pacheu‐Grau D., Pape J. K., Stoldt S., Huser T., Hell S. W., Möbius W., Rehling P., Riedel D., Jakobs S.: "MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation"
The EMBO Journal, e104105. DOI https://doi.org/10.15252/embj.2019104105. Comment in EMBO JournalDetails

Woodhouse J., Kovacs G.N., Coquelle N., Uriarte L., Adam V., Barends T.R.M., Byrdin M., De La Mora E., Doak R., Feliks M., Field M., Fieschi F., Guillon V., Jakobs S., Joti Y., Macheboeuf P., Motomura K., Nass K., Owada S., Roome C., Ruckebusch C., Schiro G., Shoeman R., Thepaut M., Togashi T., Tono K., Yabashi M., Cammarata M., FoucarL., Bourgeois D., SliwaM.,Colletier J.P.,Schlichting I., WeikW.: "Photoswitching mechanism of a fluorescent protein revealed by time-resolved crystallography and transient absorption spectroscopy"
Nature Communications 11. DOI 10.1038/s41467-020-14537-0Details

Toth A., Meyrat A., Stoldt S., Santiago R., Wenzel D., Jakobs S., von Ballmoos C., Ott M.: "Kinetic coupling of the respiratory chain with ATP synthase, but not proton gradients, drives ATP production in cristae membranes"
Proc. Natl. Acad. Sci. USA 117, 2412-2421. DOI 10.1073/pnas.1917968117Details

2019

Stephan T., Roesch A., Riedel D., Jakobs S.: "Live-cell STED nanoscopy of mitochondrial cristae"
Scientific Reports 9, 12419. DOI 10.1038/s41598-019-48838-2. Access the Publication via Access the Publication via SN SharedIt This publication is one of the Top 100 downloaded Scientific Reports articles in Cell and Molecular Biology of 2019!Details

Wurm C.A., Schwarz H., Jans D.C., Riedel D., Humbel B.M., Jakobs S.: "Correlative STED super-resolution light and electron microscopy on resin sections"
Journal of Physics D: Applied Physics 52. DOI 10.1088/1361-6463/ab2b31Details

Frahm L., Keller-Findeisen J., Alt P., Schnorrenberg S., del Alamo Ruiz M., Aspelmeier T., Munk A., Jakobs S., Hell S.W.: "Molecular contribution function in RESOLFT nanoscopy"
Optics Express 27, 21956-21987. DOI 10.1364/OE.27.021956Details

Ramos E.S., Motori E., Brüser C., Kühl I., Yeroslaviz A., Ruzzenente B., Kauppila J.H., Busch J.D., Hultenby K., Habermann B.H., Jakobs S., Larsson N.G., Mourier A.: "Mitochondrial fusion is required for regulation of mitochondrial DNA replication"
PLOS Genetics 15, e1008085. DOI 10.1371/journal.pgen.1008085Details

Callegari S., Müller T., Schulz C., Lenz C., Jans D.C., Wissel M., Opazo F., Rizzoli S.O., Jakobs S., Urlaub H., Rehling P., Deckers M.: "A MICOS-TIM22 Association Promotes Carrier Import into Human Mitochondria."
Journal of Molecular Biology 431, 2835-2851. DOI 10.1016/j.jmb.2019.05.015Details

Stoldt S., Stephan T., Jans D.C., Brüser C., Lange F., Keller-Findeisen J., Riedel D., Hell S.W., Jakobs S.: "Mic60 exhibits a coordinated clustered distribution along and across yeast and mammalian mitochondria"
Proc. Natl. Acad. Sci. USA 116, 9853-9858. DOI 10.1073/pnas.1820364116Details

Tuijtel M.W., Koster A.J., Jakobs S., Faas F.G.A., Sharp T.H.: "Correlative cryo super-resolution light and electron microscopy on mammalian cells using fluorescent proteins"
Scientific Reports 9, 1369. DOI 10.1038/s41598-018-37728-8Details

Richter F., Dennerlein S., Nikolov M., Jans D.C., Naumenko N., Aich A., MacVicar T., Linden A., Jakobs S., Urlaub H., Langer T., Rehling P.: "ROMO1 is a constituent of the human presequence translocase required for YME1L protease import"
Journal of Cell Biology 218, 598-614. DOI 10.1083/jcb.201806093Details

2018

Kamper M., Ta H., Jensen N.A., Hell S.W., Jakobs S.: "Near-infrared STED nanoscopy with an engineered bacterial phytochrome"
Nature Communications 9, 4762. DOI 10.1038/s41467-018-07246-2. Access the Publication via Access the Publication via SN SharedItDetails

Butkevich A.N., Ta H., Ratz M., Stoldt S., Jakobs S., Belov V.N., Hell S.W.: "Two-Color 810 nm STED Nanoscopy of Living Cells with Endogenous SNAP-Tagged Fusion Proteins."
ACS Chemical Biology 13, 475-480. DOI 10.1021/acschembio.7b00616Details

Faoro F., Bassu M., Mejia Y.X., Stephan T., Dudani N., Boeker S., Jakobs S., Burg T.P.: "Aberration-corrected cryoimmersion light microscopy"
Proc. Natl. Acad. Sci. USA 115, 1204-1209. DOI 10.1073/pnas.1717282115Details

Coquelle N., Sliwa M., Woodhouse J., Schiro G., Adam V., Aquila A., Barends T., Boutet S., Byrdin M., Carbajo S., de la Mora E., Doak Feliks M., Fieschi F., Foucar L., Guillon V., Hilpert M., Hunter M., Jakobs S., Koglin J., Kovacsova G., Lane T., Lévy B., Liang M., Nass K., Ridard J., Robinson J., Roome C., Ruckebusch C., Seaberg M., Thepaut M., Cammarata M., Demac: "Chromophore twisting in the excited state of a photoswitchable fluorescent protein captured by time-resolved serial femtosecond crystallography"
Nature Chemistry 10, 31-37. DOI 10.1038/nchem.2853Details

2017

Sahl S.J., Hell S.W., Jakobs S.: "Fluorescence nanoscopy in cell biology"
Nature Reviews Molecular Cell Biology 18, 685-701. DOI 10.1038/nrm.2017.71. Access the Publication via Access the Publication via SN SharedItDetails

Tarasenko D., Barbot M., Jans D.C., Kroppen B., Sadowski B., Heim G., Möbius W., Jakobs S., Meinecke M.: "The MICOS component Mic60 displays a conserved membrane-bending activity that is necessary for normal cristae morphology"
Journal of Cell Biology 216, 889-899. DOI 10.1083/jcb.201609046Details

Chmyrov A., Leutenegger M., Grotjohann T., Schönle A., Keller-Findeisen J., Kastrup L., Jakobs S., Donnert G., Sahl S.J., Hell S.W.: "Achromatic light patterning and improved image reconstruction for parallelized RESOLFT nanoscopy"
Scientific Reports 7, 44619. DOI 10.1038/srep44619Details

2016

Sahl S.J., Balzarotti F., Keller-Findeisen J., Leutenegger M., Westphal V., Egner A., Lavoie-Cardinal F., Chmyrov A., Grotjohann T., Jakobs S.: "Comment on “Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics”"
Science 352, 527. DOI 10.1126/science.aad7983Details

Schnorrenberg S., Grotjohann T., Vorbrüggen G., Herzig A., Hell S.W., Jakobs S.: "In vivo super-resolution RESOLFT microscopy of Drosophila melanogaster"
eLIFE 5, e15567. DOI 10.7554/eLife.15567. Highlighted in Nature Methods.Details

Callegari S., Richter F., Chojnacka K., Jans D.C., Lorenzi I., Pacheu-Grau D., Jakobs S., Lenz C., Urlaub H., Dudek J., Chacinska A., Rehling P.: "TIM29 is a subunit of the human carrier translocase required for protein transport"
FEBS Letters 590, 4147–4158. DOI 10.1002/1873-3468.12450Details

2015

Walter A., Andresen M., Jakobs S., Schroeder J., Schwarzer D.: "Primary Light-Induced Reaction Steps of Reversibly Photoswitchable Fluorescent Protein Padron0.9 Investigated by Femtosecond Spectroscopy"
The Journal of Physical Chemistry B119, 5136–5144. DOI 10.1021/jp512610qDetails

Kehrein K., Schilling R., Möller-Hergt B.V., Wurm C.A., Jakobs S., Lamkemeyer T., Langer T., Ott, M.: "Organization of Mitochondrial Gene Expression in Two Distinct Ribosome-Containing Assemblies"
Cell Reports 10, 843–853. DOI 10.1016/j.celrep.2015.01.012Details

Ratz M., Testa I., Hell S.W., Jakobs S.: "CRISPR/Cas9-mediated endogenous protein tagging for RESOLFT super-resolution microscopy of living human cells"
Scientific Reports 5, 9592. DOI 10.1038/srep09592. This publication is one of the Top 100 read Scientific Reports articles in 2015! Access the recommendation on F1000PrimeDetails

Kukat C., Davies K.M., Wurm C.A., Spåhr H., Bonekamp N.A., Kühl I., Joos F., Polosa P.L., Park C.B., Posse V., Falkenberg M., Jakobs S., Kühlbrandt W., Larsson N.G.: "Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid."
Proc. Natl. Acad. Sci. USA 112, 11288-93. DOI 10.1073/pnas.1512131112Details

Dennerlein S., Oeljeklaus S., Jans D.C., Hellwig C., Bareth B., Jakobs S., Deckers M., Warscheid B., Rehling P.: "MITRAC7 Acts as a COX1-Specific Chaperone and Reveals a Checkpoint during Cytochrome c Oxidase Assembly."
Cell Reports 12, 1644-55. DOI 10.1016/j.celrep.2015.08.009Details

Duwé S., De Zitter E., Gielen V., Moeyaert B., Vandenberg W., Grotjohann T., Clays K., Jakobs S., Van Meervelt L., Dedecker P.: "Expression-Enhanced Fluorescent Proteins Based on Enhanced Green Fluorescent Protein (EGFP) for Super-Resolution Microscopy."
ACS Nano 10, 9528–9541. DOI 10.1021/acsnano.5b04129Details

Ilgen P., Grotjohann T., Jans D.C., Kilisch M., Hell S.W., Jakobs S.: "RESOLFT Nanoscopy of Fixed Cells Using a Z-Domain Based Fusion Protein for Labelling"
PLoS One 10, e0136233. DOI 10.1371/journal.pone.0136233Details

Sakowska P., Jans D.C., Mohanraj K., Riedel D., Jakobs S., Chacinska A.: "The oxidation status of Mic19 regulates MICOS assembly"
Molecular and Cellular Biology 35, 4222-4237. DOI 10.1128/MCB.00578-15Details

Hell S.W., Sahl S.J., Bates M., Zhuang X., Heintzmann R., Booth M.J., Bewersdorf J., Shtengel G., Hess H., Tinnefeld P., Honigmann A., Jakobs S., Testa I., Cognet L., Lounis B., Ewers H., Davis S.J., Eggeling C., Klenerman D., Willig K.I., Vicidomini G., Castello M.: "The 2015 super-resolution microscopy roadmap"
Journal of Physics D: Applied Physics 48, 443001. DOI doi:10.1088/0022-3727/48/44/443001Details

2014

Jensen N.A., Danzl J.G., Willig K.I., Lavoie-Cardinal F., Brakenmann T., Hell S.W., Jakobs S.: "Coordinate-Targeted and Coordinate-Stochastic Super-Resolution Microscopy with the Reversibly Switchable Fluorescent Protein Dreiklang"
ChemPhysChem 15, 756-762. DOI 10.1002/cphc.201301034Details

Lavoie-Cardinal F., Jensen N.A., Westphal V., Stiel A.C., Chmyrov A., Bierwagen J., Testa I., Jakobs S., Hell S.W.: "Two-Color RESOLFT Nanoscopy with Green and Red Fluorescent Photochromic Proteins"
ChemPhysChem 15, 655-663. DOI 10.1002/cphc.201301016. Journal Cover ChemPhysChem Mar. 2014.Details

Pfanner N., van der Laan M., Amati P., Capaldi R.A., Caudy A.A., Chacinska A., Darshi M., Deckers M., Hoppins S., Icho T., Jakobs S., Ji J., Kozjak-Pavlovic V., Meisinger C., Odgren P.R., Park S.K., Rehling P., Reichert A.S., Sheikh M.S., Taylor S.S., Tsuchida N., van der Bliek A.M., van der Klei I.J., Weissman J.S., Westermann B., Zha J., Neupert W., Nunnari J.: "Uniform nomenclature for the mitochondrial contact site and cristae organizing system"
Journal of Cell Biology 204, 1083-1086. DOI 10.1083/jcb.201401006Details

Ilgen P., Stoldt S., Conradi L.C., Wurm C.A., Rüschoff J., Ghadimi B.M., Liersch T., Jakobs S.: "STED Super-Resolution Microscopy of Clinical Paraffin-Embedded Human Rectal Cancer Tissue"
PLoS ONE 9, e101563. DOI 10.1371/journal.pone.0101563Details

Geissbuehler S., Sharipov A., Godinat A., Bocchio N.L., Sandoz P.A., Huss A., Jensen N.A., Jakobs S., Enderlein J., van der Goot F.G., Dubikovskaya E.A., Lasser T., Leutenegger M.: "Live-cell multiplane three-dimensional super-resolution optical fluctuation imaging"
Nature Communications 5. DOI 10.1038/ncomms6830Details

2013

Jans D.C., Wurm C.A., Riedel D., Wenzel D., Stagge F., Deckers M., Rehling R., Jakobs S.: "STED super-resolution microscopy reveals an array of MINOS clusters along human mitochondria"
Proc. Natl. Acad. Sci. USA 110, 8936-8941. DOI 10.1073/pnas.1301820110Details

2012

Alkhaja A.K., Jans D.C., Nikolov M., Vukotic M., Lytovchenko O., Ludewig F., Schliebs W., Riedel D., Urlaub H., Jakobs S., Deckers M.: "MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization"
Molecular Biology of the Cell 23, 247-257. DOI 10.1091/mbc.E11-09-0774Details

Grotjohann T., Testa I., Reuss M., Brakemann T., Eggeling C., Hell S.W., Jakobs S.: "rsEGFP2 enables fast RESOLFT nanoscopy of living cells"
ELife 1, e00248. DOI 10.7554/eLife.00248. Highlighted in The Scientist.Details

Kolmakov K., Wurm C.A., Hennig R., Rapp E., Jakobs S., Belov V.N., Hell S.W.: "Red-Emitting Rhodamines with Hydroxylated, Sulfonated, and Phosphorylated Dye Residues and Their Use in Fluorescence Nanoscopy"
Chemistry A European Journal 18, 12986-12998. DOI 10.1002/chem.201201168Details

Stoldt S., Wenzel W., Hildenbeutel M., Wurm C.A., Herrmann J.M., Jakobs S.: "The inner-mitochondrial distribution of Oxa1 depends on the growth conditions and on the availability of substrates"
Molecular Biology of the Cell 23, 2292-2301. DOI 10.1091/mbc.E11-06-0538Details

Vukotic M., Oeljeklaus S., Wiese S., Vögtle N.F., Meisinger C., Meyer H.E., Zieseniss A., Katschinski D.M., Jans D.C., Jakobs S., Warscheid B., Rehling P., Deckers M.: "Rcf1 Mediates Cytochrome Oxidase Assembly and Respirasome Formation, Revealing Heterogeneity of the Enzyme Complex"
Cell Metabolism 15, 336-347. DOI 10.1016/j.cmet.2012.01.016. Highlighted in Cell Metabolism.Details

2011

Brakemann T., Stiel A.C., Weber G., Andresen M., Testa I., Grotjohann T., Leutenegger M., Plessmann U., Urlaub H., Eggeling C., Wahl M.C., Hell S.W.*, Jakobs S.*: "A reversibly photoswitchable GFP-like protein with fluorescence excitation decoupled from switching"
Nature Biotechnology 29, 942-947. DOI 10.1038/nbt.1952. (*shared corresponding authors) Highlighted in Nature Biotechnoloy. Journal Cover Nature Biotechnology Oct. 2011. Access the recommendation on F1000PrimeDetails

Grotjohann T., Testa I., Leutenegger M., Bock H., Urban N.T., Lavoie-Cardinal F., Willig K.I., Eggeling C., Jakobs S.*, Hell, S.W.*: "Diffraction-unlimited all-optical imaging and writing with a photochromic GFP"
Nature 478, 204-208. DOI 10.1038/nature10497. (*shared corresponding authors) Access the recommendation on F1000PrimeDetails

Jakobs S., Stoldt S., Neumann D.: "Light Microscopic Analysis of Mitochondrial Heterogeneity in Cell Populations and Within Single Cells"
Advances in Biochemical Engineering/Biotechnology 124, 1-19. DOI 10.1007/10_2010_81Details

Kleine-Vehn J., Wabnik K., Martiniere A., Langowski L., Willig K., Naramoto S., Leitner J., Tanaka H., Jakobs S., Robert S., Luschnig C., Govaerts W., Hell S.W., Runions J., Friml J.: "Recycling, clustering, and endocytosis jointly maintain PIN auxin carrier polarity at the plasma membrane"
Molecular Systems Biology 7, 540. DOI 10.1038/msb.2011.72Details

Kukat C.,Wurm C.A., Spahr H.,Falkenberg M., Larsson N., Jakobs S.: "Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA"
Proc. Natl. Acad. Sci. USA 108, 13534-13539. DOI 10.1073/pnas.1109263108Details

Willig K.I., Stiel A.C., Brakemann T., Jakobs S., Hell S.W.: "Dual-Label STED Nanoscopy of Living Cells Using Photochromism"
Nano Letters 11, 3970-3973. DOI 10.1021/nl202290wDetails

Wurm C.A., Neumann D., Lauterbach M.A., Harke B., Egner A., Hell S.W., Jakobs S.: "Nanoscale distribution of mitochondrial import receptor Tom20 is adjusted to cellular conditions and exhibits an inner-cellular gradient"
Proc. Natl. Acad. Sci. USA 108, 13546-13551. DOI 10.1073/pnas.1107553108Details

2010

Bierwagen J., Testa I., Foelling J., Wenzel D., Jakobs S., Eggeling C., Hell S.W.: "Far-Field Autofluorescence Nanoscopy"
Nano Letters 10, 4249-4252. DOI 10.1021/nl1027638Details

Brakemann T., Weber G., Andresen M., Groenhof G., Stiel A.C., Trowitzsch S., Eggeling C., Grubmueller H., Hell S.W., Wahl M.C., Jakobs S.: "Molecular Basis of the Light-driven Switching of the Photochromic Fluorescent Protein Padron"
Journal of Biological Chemistry 285, 14603-14609. DOI 10.1074/jbc.M109.086314Details

Hein B., Willig K.I., Wurm C.A., Westphal V., Jakobs S., Hell S.W.: "Stimulated Emission Depletion Nanoscopy of Living Cells Using SNAP-Tag Fusion Proteins"
Biophysical Journal 98, 158-163. DOI 10.1016/j.bpj.2009.09.053Details

Mitronova G.Y., Belov V.N., Bossi M.L., Wurm C.A., Meyer L., Medda R., Moneron G., Bretschneider S., Eggeling C., Jakobs S., Hell S.W.: "New Fluorinated Rhodamines for Optical Microscopy and Nanoscopy"
Chemistry A European Journal 16, 4477-4488. DOI 10.1002/chem.200903272Details

Neumann D., Buckers J., Kastrup L., Hell S.W., Jakobs S.: "Two-color STED microscopy reveals different degrees of colocalization between hexokinase-I and the three human VDAC isoforms"
PMC Biophysics 3. DOI 10.1186/1757-5036-3-4Details

Testa I., Wurm C.A., Medda R., Rothermel E., von Middendorf C., Foelling J., Jakobs S., Schoenle A., Hell S.W., Eggeling C.: "Multicolor Fluorescence Nanoscopy in Fixed and Living Cells by Exciting Conventional Fluorophores with a Single Wavelength"
Biophysical Journal 99, 2686-2694. DOI 10.1016/j.bpj.2010.08.012Details

Wurm, C.A.,Neumann, D.,Schmidt, R.,Egner, A. and Jakobs, S.: "Sample Preparation for STED Microscopy"
Live Cell Imaging: Methods and Protocols 591, 185-199. DOI 10.1007/978-1-60761-404-3_11Details

2009

Suppanz I.E., Wurm C.A., Wenzel D., Jakobs S.: "The m-AAA Protease Processes Cytochrome c Peroxidase Preferentially at the Inner Boundary Membrane of Mitochondria"
Molecular Biology of the Cell 20, 572-580. DOI 10.1091/mbc.E07-11-1112Details

2008

Altmann K., Frank M., Neumann D., Jakobs S., Westermann, B.: "The class V myosin motor protein, Myo2, plays a major role in mitochondrial motility in Saccharomyces cerevisiae"
Journal of Cell Biology 181, 119-130. DOI 10.1083/jcb.200709099. Access the recommendation on F1000PrimeDetails

Andresen M., Stiel A.C., Foelling J., Wenzel D., Schoenle A., Egner A., Eggeling C., Hell S.W., Jakobs, S.: "Photoswitchable fluorescent proteins enable monochromatic multilabel imaging and dual color fluorescence nanoscopy"
Nature Biotechnology 26, 1035-1040. DOI 10.1038/nbt.1493. Highlighted in Nature Methods and Nature Chemical Biology. Access the recommendation on F1000PrimeDetails

Foelling J., Bossi M., Bock H., Medda R., Wurm C.A., Hein B., Jakobs S., Eggeling C., Hell S.W.: "Fluorescence nanoscopy by ground-state depletion and single-molecule return"
Nature Methods 5, 943-945. DOI 10.1038/nmeth.1257Details

Stiel A.C., Andresen M., Bock H., Hilbert M., Schilde J., Schoenle A., Eggeling C., Egner A., Hell S.W., Jakobs S.: "Generation of monomeric reversibly switchable red fluorescent proteins for far-field fluorescence nanoscopy"
Biophysical Journal 95, 2989-2997. DOI 10.1529/biophysj.108.130146. Highlighted in Nature Methods.Details

Testa I., Schoenle A., Middendorff C., Geisler C., Medda R., Wurm C.A., Stiel A.C., Jakobs S., Bossi M., Eggeling C., Hell S.W., Egner A.: "Nanoscale separation of molecular species based on their rotational mobility"
Optics Express 16, 21093-21104. DOI 10.1364/oe.16.021093Details

2007

Andresen M., Stiel A.C., Trowitzsch S., Weber G., Eggeling C., Wahl M.C., Hell S.W., Jakobs, S.: "Structural basis for reversible photoswitching in Dronpa"
Proc. Natl. Acad. Sci. USA 104 (32), 13005-13009. DOI 10.1073/pnas.0700629104Details

Bock H., Geisler C., Wurm C.A., von Middendorff C., Jakobs S., Schönle A., Egner A., Hell S.W., Eggeling C.: "Two-color far-field fluorescence nanoscopy based on photoswitchable emitters"
Applied Physics B 88 (2), 161-165. DOI 10.1007/s00340-007-2729-0Details

Donnert G., Keller J., Wurm C.A., Rizzoli S.O., Westphal V., Schönle A., Jahn R., Jakobs S., Eggeling C., Hell S.W.: "Two-color far-field fluorescence nanoscopy"
Biophysical Journal 92 (8), L67-L69. DOI 10.1529/biophysj.107.104497. Access the recommendation on F1000PrimeDetails

Eggeling C., Hilbert M., Bock H., Ringemann C., Hofmann M., Stiel A.C., Andresen M., Jakobs S., Egner A., Schönle A., Hell S.W.: "Reversible photoswitching enables single-molecule fluorescence fluctuation Spectroscopy at high molecular concentration"
Microscopy Research and Technique 70 (12), 1003-1009. DOI 10.1002/jemt.20505Details

Egner A., Geisler C., von Middendorff C., Bock H., Wenzel D., Medda R., Andresen M., Stiel A.C., Jakobs S., Eggeling C., Schönle A., Hell S.W.: "Fluorescence nanoscopy in whole cells by asynchronous localization of photoswitching emitters"
Biophysical Journal 93 (9), 3285-3290. DOI 10.1529/biophysj.107.112201Details

Meuer K., Suppanz I.E., Lingor P., Planchamp V., Göricke B., Fichtner L., Braus G.H., Dietz G.P.H., Jakobs S., Bähr M., Weishaupt J.H.: "Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis"
Cell Death and Differentiation 14 (4), 651-661. DOI 10.1038/sj.cdd.4402087Details

Schwentker M., Bock H., Hofmann M., Jakobs S., Bewersdorf J., Eggeling C., Hell S.W.: "Wide-field subdiffraction RESOLFT microscopy using fluorescent protein photoswitching"
Microscopy Research and Technique 70 (3), 269-280. DOI 10.1002/jemt.20443Details

Stiel A.C., Trowitzsch S., Weber G., Andresen M., Eggeling C., Hell S.W., Jakobs S., Wahl M.C.: "1.8 angstrom bright-state structure of the reversibly switchable fluorescent protein Dronpa guides the generation of fast switching variants"
Biochemical Journal 402, 35-42. DOI 10.1042/bj20061401Details

2006

Medda R, Jakobs S., Hell S.W., Bewersdorf J.: "4Pi microscopy of quantum dot-labeled cellular structures"
Journal of Structural Biology 156 (3), 517-523. DOI 10.1016/j.jsb.2006.08.013Details

Schauss A.S., Bewersdorf J., Jakobs S.: "Fis1p and Caf4p, but not Mdv1p, determine the polar localization of Dnm1p clusters on the mitochondrial surface"
Journal of Cell Science 119 (15), 3098-3106. DOI 10.1242/jcs.03026Details

Willig K.I., Kellner R.R., Medda R., Jakobs S., Hell S.W.: "Nanoscale resolution in GFP-based microscopy"
Nature Methods 3 (9), 721-723. DOI 10.1038/nmeth922Details

Wurm C.A., Jakobs S.: "Differential protein distributions define two sub-compartments of the mitochondrial inner membrane in yeast"
FEBS Letters 580 (24), 5628-5634. DOI 10.1016/j.febslet.2006.09.012Details

2005

Andresen M., Wahl M.C., Stiel A.C., Gräter F., Schäfer L.V., Trowitzsch S., Weber G., Eggeling C., Grubmüller H., Hell S.W., Jakobs S.: "Structure and mechanism of the reversible photoswitch of a fluorescent protein"
Proc. Natl. Acad. Sci. USA 102 (37), 13070-13074. DOI 10.1073/pnas.0502772102Details

Dimmer, K.S.,Jakobs, S.,Vogel, F.,Altmann, K. and Westermann, B.: "Mdm31 and Mdm32 are inner membrane proteins required for maintenance of mitochondrial shape and stability of mitochondrial DNA nucleoids in yeast"
J. Cell Biol. 168 (1), 103-115. DOI 10.1083/jcb.200410030. Access the recommendation on F1000PrimeDetails

Hofmann M., Eggeling C., Jakobs S., Hell S.W.: "Breaking the diffraction barrier in fluorescence microscopy at low light intensities by using reversibly photoswitchable proteins"
Proc. Natl. Acad. Sci. USA 102 (49), 17565-17569. DOI 10.1073/pnas.0506010102. Access the recommendation on F1000PrimeDetails

2004

Andresen M., Schmitz-Salue R., Jakobs S.: "Short tetracysteine tags to beta-tubulin demonstrate the significance of small labels for live cell imaging"
Molecular Biology of the Cell 15 (12), 5616-5622. DOI 10.1091/mbc.E04-06-0454Details

Gugel H., Bewersdorf J., Jakobs S., Engelhardt J., Storz R., Hell S.W.: "Cooperative 4Pi excitation and detection yields sevenfold sharper optical sections in live-cell microscopy"
Biophysical Journal 87 (6), 4146-4152. DOI 10.1529/biophysj.104.045815Details

2003

Hell, S.W.,Jakobs, S. and Kastrup, L.: "Imaging and writing at the nanoscale with focused visible light through saturable optical transitions"
Appl. Phys. A 77 (7), 859-860. DOI 10.1007/s00339-003-2292-4Details

Jakobs, S.,Martini, N.,Schauss, A.C.,Egner, A.,Westermann, B. and Hell, S.W.: "Spatial and temporal dynamics of budding yeast mitochondria lacking the division component Fis1p"
J. Cell Sci. 116 (10), 2005-2014. DOI 10.1242/jcs.00423Details

Jakobs, S.,Schauss, A.C. and Hell, S.W.: "Photoconversion of matrix targeted GFP enables analysis of continuity and intermixing of the mitochondrial lumens"
FEBS Letters 554 (1-2), 194-200. DOI 10.1016/s0014=5793(03)01170-0Details

Messerschmitt, M.,Jakobs, S.,Vogel, F.,Fritz, S.,Dimmer, K.S.,Neupert, W. and Westermann, B.: "The inner membrane protein Mdm33 controls mitochondrial morphology in yeast"
J. Cell Biol. 160 (4), 553-564. DOI 10.1083/jcb.200211113. Access the recommendation on F1000PrimeDetails

2002

Egner, A.,Jakobs, S. and Hell, S.W.: "Fast 100-nm resolution three-dimensional microscope reveals structural plasticity of mitochondria in live yeast"
PNAS 99 (6), 3370-3375. DOI 10.1073/pnas.052545099Details

Kano, H.,Jakobs, S.,Nagorni, M. and Hell, S.W.: "Dual-color 4Pi-confocal microscopy with 3D-resolution in the 100 nm range"
Ultramicroscopy 90 (2-3), 207-213. DOI 10.1016/s0304-3991(01)00132-2Details

2001

2000

Dyba, M.,Klar, T.A.,Jakobs, S. and Hell, S.W.: "Ultrafast dynamics microscopy"
Appl. Phys. Lett. 77 (4), 597-599. DOI 10.1063/1.127056Details

Jakobs, S.,Subramaniam, V.,Schonle, A.,Jovin, T.M. and Hell, S.W.: "EGFP and DsRed expressing cultures of Escherichia coli imaged by confocal, two-photon and fluorescence lifetime microscopy"
FEBS Letters 479 (3), 131-135. DOI 10.1016/s0014-5793(00)01896-2Details

Klar, T.A.,Jakobs, S.,Dyba, M.,Egner, A. and Hell, S.W.: "Fluorescence microscopy with diffraction resolution barrier broken by stimulated emission"
PNAS 97 (15), 8206-8210. DOI 10.1073/pnas.97.15.8206. Highlighted in PNAS.Details