Bibliographic Data
- Authors: Belov V.N., Wurm C.A., Boyarskiy V.P., Jakobs S., Hell S.W.
- Title: Rhodamines NN: A Novel Class of Caged Fluorescent Dyes
- Journal: Angewandte Chemie - International Edition
- Volume: 49
- Volume: 3520-3523
- DOI: 10.1002/anie.201000150
Highlighted in Nature Chemistry.
Journal Cover Angewandte Chemie Apr. 2010.
Abstract
A bright future: The reaction of diazomethane with acid chlorides obtained from N,N,N′,N′-tetraalkylrhodamines affords 2-diazo-2,3-dihydro-1H-indenespiro[1,9′]-9H-xanthen-3-ones—a novel class of caged rhodamines. These dyes allow new imaging procedures based on the step-wise activation and detection of several fluorescent markers.